Tretinoin can be used with alpha hydroxy acids (AHAs) for additional skin-smoothing effects. Because they're not as strong (and thus less irritating), they are not as effective in reducing wrinkles as tretinoin but they do improve the appearance of photo-aged skin. In addition, several over-the-counter products containing retinoids, such as retinol, are available. Other retinoids are undergoing clinical trials. Adapalene is also available over the counter (in a 0.1% formulation versus the 0.3% prescription version). Tretinoin (Retin-A, generic), tazarotene (Avage, Tazorac), and adapalene (Differin) are prescription retinoids. These drugs must be used continually to maintain their benefits. The safety and scientific validity of this. Wear a sunscreen during the day because retinoids increase the skin's sensitivity to sunlight. Comparison of Retinol 1.0 and Tretinoin 0.02 in the Treatment of Moderate to Severe Photodamage and Wrinkles. However, it takes three to six months of regular use before improvements in wrinkles are apparent-and the best results take six to 12 months.īecause retinoids can cause skin dryness and irritation, doctors often recommend using them only every other day at first and then gradually working up to nightly applications. Additional benefits include fading age spots and softening rough patches of skin. They also stimulate the production of new blood vessels in the skin, which improves skin color. Retinoids reduce fine lines and wrinkles by increasing the production of collagen. It was used as an acne treatment in the 1970s, but researchers later discovered that it also fades actinic keratosis spots, evens pigmentation, and speeds the turnover of superficial skin cells. Tretinoin, under the brand name Retin-A, was the first retinoid. Topical vitamin A–based drugs called retinoids-the most used and most studied anti-aging compounds- may reduce fine lines and wrinkles.
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